The Optimized Irvingia with Phase 3 Calorie Control Complex formulation
provides a combination of natural compounds that combat age-related fat
accumulation via the following eight distinct mechanisms:
Delaying digestion and absorption of sucrose.
Enhancing resting energy expenditure at the cellular level.
Slowing the absorption of dietary fat from the intestines.
Moderating alpha-amylase enzyme activity to reduce the absorption of carbohydrates into the bloodstream.
Reducing alpha-glucosidase enzyme activity to further slow the absorption of starches and sugars into the bloodstream.
Supporting leptin sensitivity to stimulate lipolysis.
7. Supporting youthful levels of adiponectin to help maintain healthy insulin sensitivity.
8. Moderating glycerol-3-phosphate dehydrogenase enzyme activity to
reduce the amount of ingested starches that are converted to
triglycerides and stored as fat.
Phase 3 Sucrase Modulator
A recent study in the journal Science concluded that in primates a
calorie-restricted diet can delay disease onset and age-related
mortality.28 While Life Extension readers understand the benefits of
calorie restriction, that doesnt make it any easier to cut back on one
of the major calorie culprits in the American diet: refined sugar.
is an enzyme that breaks down sucrose in the digestive tract for
absorption into the bloodstream. Phase 3 is a patented compound that
functions as a beneficial sucrase modulator. It contains L-Arabinose, a
natural substance found in plants that reduces the number of absorbed
calories from sugar. Phase 3 can help support healthy insulin
metabolism and sugar levels in the bloodstream. Phase3 is just one
ingredient in Optimized Irvingia.
Green Tea Phytosome Cellular Energy Enhancer
ability of green tea extracts to inhibit the breakdown and absorption
of dietary fat has been the subject of research studies across the
globe. Mounting scientific research has documented the metabolic effects
of green tea polyphenols. A proprietary phytosome complex has shown an
ability to increase the absorption of green tea polyphenols into the
bloodstream better than conventional tea extracts resulting in peak
plasma levels of the critical green tea polyphenol
Participants in a human clinical
trial showed an average weight loss of 30 pounds and a 10% reduction in
waist circumference in 90 days when 300 mg/day of this new green tea
phytosome was taken in conjunction with a reduced-calorie diet.29 The
placebo group that followed the same reduced-calorie diet lost only 9.9
pounds and only 5% of their waist size. Optimized Irvingia contains the
exact same green tea phytosome as was used in this study.
The Alpha-Amylase Enzyme
reduces our ability to utilize the carbohydrates (and fats) that
constitute what most would consider part of a healthy diet. The result
is that as we grow older, our bloodstreams become chronically bloated
with glucose and triglycerides in direct contrast to the youthful
metabolic profile we have in our younger years. Emerging scientific
research suggests that the alpha-amylase enzyme plays an undesirable
role in the digestion of dietary carbohydrates and subsequent absorption
of calories from starch and sugar. A natural bean extract (Phaseolus
vulgaris) moderates alpha-amylase activity. In a human trial in which
all overweight participants were placed on a 2,0002,200-calorie,
carbohydrate-rich diet, those taking Phaseolus vulgaris lost 6.5 pounds
and 1.2 inches in waist size in only 30 days compared with 0.8 pounds
and 0.2 inches in the placebo group.30 Optimized Irvingia contains the
identical Phaseolus vulgaris used in this study.
The Alpha-Glucosidase Enzyme
intestinal enzyme that enables carbohydrate absorption is
alpha-glucosidase. A patented seaweed extract (InSea2) has demonstrated
the ability to help maintain healthy levels of both alpha-glucosidase
and alpha-amylase. When given to laboratory animals, this seaweed
extract reduced after-meal (postprandial) glucose elevations by up to
90% compared with non-supplemented animals.31
healthy individuals rapidly convert ingested fats and sugars into
energy. Age-related changes decrease our metabolic capacity to
efficiently utilize dietary fats and sugars. It is thus paramount for
aging people to reduce their absorption of excess calories. By taking
nutrients before each meal that reduce the activity of carbohydrate and
fat digesting enzymes, the calorie burden is significantly reduced.
Optimized Irvingia provides the same InSea2 extract as used in
cells (adipocytes) secrete a hormone called leptin that tells our brain
we have eaten enough. Leptin can also facilitate the breakdown of
stored triglycerides in our adipocytes via the process of lipolysis.
Heavy individuals have startlingly high blood levels of leptin,
indicating that their cells have become resistant to the leptin that is
supposed to prevent them from putting on so many fat pounds.
extract from a West African food called Irvingia gabonensis has been
shown to help support leptin sensitivity in overweight people. In a
recently published study, Irvingia demonstrated beneficial effects upon
leptin blood levels, followed by weight loss and inches off the
waistline.32 In addition to supporting healthy leptin sensitivity,
Irvingia has demonstrated the following beneficial effects on key
aspects of metabolism:
is an enzyme involved in the complex biochemical process that converts
ingested starch and sugar calories to stored body fat. Irvingia has been
shown in studies involving fat cells to reduce the activity of
glycerol-3-phosphate dehydrogenase,33 which may help reduce the impact
of starch and sugar calories on body fat.
research on fat cells suggests that Irvingia has
alpha-amylase-inhibiting properties34 (like InSea2 and Phaseolus
vulgaris) which can help support a slowing of the rate of carbohydrate
absorption from the intestines and a reduction of the caloric impact of
starchy and sugary foods.35
Adiponectin is a hormone
involved in helping to maintain insulin sensitivity on the membranes of
energy-producing cells. Big fat cells produce less adiponectin, and
overweight people need to be especially concerned about maintaining
healthy levels of adiponectin to support insulin sensitivity and
metabolic fitness. Scientific data suggests that Irvingia helps support
healthy adiponectin levels.33
Optimized Irvingia with Phase 3
Calorie Control Complex is indeed an innovative multi-modal approach to
weight loss with an additional benefit. By helping to slow the
absorption of starches and sugars, it reduces their caloric impact. And
according to a recent mammalian study, those following a
calorie-restricted diet were shown to significantly reduce the risk of
mortality from age-related causes.28 This suggests that regular
supplementation with this or any Irvingia formulation may help provide
anti-aging benefits similar to those found in this recent study.
Supplements should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.
Serving Size 2 capsules
Servings Per Container 60
Amount Per Serving
Iodine (typical value naturally occurring from Ascophyllum nodosum and Fucus vesiculosus): 37.5 mcg
Chromium (as Chromium GlycoProtein Matrix): 100 mcg
Integra-Lean Irvingia gabonensis proprietary extract (seed) :150 mg
Calorie Control Complex providing:
InSea2 [proprietary composition of demineralized polyphenols from brown seaweeds Kelp (Ascophyllum
nodosum) and Bladderwrack (Fucus vesiculosus)] 125 mg
TeaSlender Green Tea Phytosome Green Tea (Camellia sinensis) Phytosome
decaffeinated extract (leaf) containing standardized green tea extract
bound to phosphatidylcholine (from lecithin) 150 mg
Phase 2 Phaseolus vulgaris white kidney (bean) extract 445 mg
Phase 3 Sucrase Inhibitor L-Arabinose and Chromium GlycoProtein Matrix
(supplying 475 mg L-arabinose and 100 mcg chromium in a food bound
state) 550 mg
Other ingredients: vegetable cellulose (capsule), stearic acid, silica, vegetable stearate, maltodextrin.
Contains soybeans and tree nuts. Contains yeast and corn.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish
(lobster, crab, shrimp), wheat, gluten or rice. Contains NO artificial
sweeteners, flavors, colors, or preservatives.
Integra-Lean Irvingia is protected by U.S. Patent No. 7,537,790. Other patents pending.
InSea2 is a trademark of innoVactiv
Phase 2 and Phase 3 are used under license.
Dosage and Use
Take two capsules twice daily 15 minutes before meals.
Best if taken before meals containing carbohydrates or starches, or as recommended by a healthcare practitioner.
Because this product may lower blood glucose, consult your healthcare provider
before taking this product if you are taking blood glucose lowering
This product is designed to target several critical factors involved in age-related
weight gain. Those who ingest more calories than what their body has the
metabolic capacity to utilize will not see results. This is because
some people are ingesting so many excess calories that no matter how
much their metabolic rate is increased, or how much improvement occurs
in their post-meal blood sugar and serum triglyceride levels, or how
much youthful insulin sensitivity and other body fat-regulating systems
are restored, they are overwhelming the metabolic capacity to utilize
these calories. This will result in excess calories being stored in
adipocytes. One cannot consume limitless calories and expect to shed fat
pounds by taking drugs, nutrients, and/or hormones that demonstrate
weight-loss effects in clinical studies.