CR Mimetic Longevity Formula

CR Mimetic Longevity Formula

In 2003, the Kurabiol Laboratories introduced a standardized extract of resveratrol, a natural compound shown to favorably alter genes implicated in the aging process many of the same genes that respond to calorie restriction or CR. In 2009, we introduced pterostilbene, a compound whose effects were found to work in synergy with resveratrol to activate your "longevity genes."

This year, we advanced the field even further, bringing together the 5 known calorie restriction mimetics in a single, high potency formula: resveratrol, pterostilbene, quercetin, grape seed polyphenols, and black tea extract.1-8 Now we announce the latest innovation in the science of longevity with new CR Mimetic Longevity Formula featuring fisetin. This little-known flavonoid is the sixth compound shown to simulate a similar youthful gene expression pattern as calorie restriction9 without significant dietary modification. In the most exciting development to date, this novel compound (fisetin) may also enhance the effects of resveratrol.10

Kurabiol Laboratories has gone to extraordinary lengths to identify compounds that simulate calorie restriction's ability to trigger youthful gene expression the process by which genes transmit signals that slow certain aspects of aging. For example, previous research funded by Kurabiol Laboratories  showed that a combination of low-dose (20 mg) resveratrol plus grape seed extract induced many of the favorable gene expression changes observed in calorie-restricted animals. A comprehensive review of the scientific literature further revealed that certain compounds found in berries, such as pterostilbene, also possess potent "longevity gene" activators that work in synergy with resveratrol.

Most abundant in strawberries, fisetin has the power to "switch on" powerful cell signaling molecules that support youthful gene expression, DNA protection, and healthy cellular function.9 It also supports aging neurons in the presence of oxidative stress.11-13 Each serving of the new CR Mimetic Longevity Formula contains fisetin in an amount equivalent to 2 cups of strawberries, helping to further emulate calorie restriction's favorable influence on your longevity genes. Most importantly, fisetin works in synergy with resveratrol. Researchers have uncovered compelling evidence of fisetin's ability to stabilize resveratrol by shielding it from metabolic breakdown10 and extending its effects.

This new formula provides cutting-edge broad spectrum support for youthful gene expression from the most scientifically validated, natural sources.

Supplement Facts

Serving size 2 vegetarian capsules
Servings per container 30

Amount per serving

Trans-Resveratrol [from Polygonum cuspidatum extract (root)] 250 mg
Trans-Pterostilbene (as pure Pterospan and SMART pterostilbene) 3 mg
Quercetin (as quercetin dihydrate) 150 mg
Masquelier's Original OPCs [single and condensed (2-5) units of flavanols & polyphenols from Vitis vinifera (grape) seeds] 50 mg
Black tea decaffeinated (Camellia sinensis) extract (leaf) [standardized to 12% TF2a theaflavin fraction (36 mg), along with TF1, TF2b and TF3 theaflavin fractions] 300 mg
Fisetin [from (Rhus succedanea L.) extract (stem)] 48 mg
Other ingredients: vegetable cellulose (capsule), stearic acid, silica.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.

Dosage and Use

Take two capsules daily with or without food, or as recommended by a healthcare practitioner.
Can be taken together or in divided doses.


1. Cell. 2006 Dec 15;127(6):1109-22.
2. Endocrinology. 2008 Jan;149(1):84-92.
3. Food Chem Toxicol. 2008 Apr;46(4):1320-6
4. Mol Nutr Food Res. 2008 Jun;52 Suppl 1:S62-70.
5. Cytokine. 2009 Aug;47(2):137-42
6. Nutr Cancer. 1999;35(1):80-6.
7. Anticancer Agents Med Chem. 2006 Sep;6(5):389-406.
8. Nature. 2006 Nov 16;444(7117):337-42.
9. Nature. 2004 Aug 5;430(7000):686-9.
10. Xenobiotica. 2000 Sep;30(9):857-66
11. Genes Nutr. 2009 Sep 10.
12. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16568-73.
13. Brain Res. 2007 Oct 10;1173:117-25.


Consult with your doctor before using this product if you have a bleeding disorder, or if you are taking anticoagulant, antiplatelet, or diabetic medications.